|
Symbol Name ID |
Lama2
laminin, alpha 2 MGI:99912 |
| Darker colors indicate more annotations |
| Human Phenotypes | Facial palsy |
Cerebral edema |
Dysphagia |
Abnormality of visual evoked potentials |
Abnormality of the nervous system |
Astrocytosis |
Abnormal brainstem MRI signal intensity |
Pontocerebellar atrophy |
Abnormal cortical gyration |
Lissencephaly |
Pachygyria |
Hypointensity of cerebral white matter on MRI |
Cognitive impairment |
Intellectual disability |
Reduced tendon reflexes |
Areflexia |
Hypokinesia |
Inability to walk |
Motor delay |
Sensorimotor neuropathy |
Seizure |
Generalized non-motor (absence) seizure |
Focal-onset seizure |
| Disease(s) Associated with LAMA2 | |||||||||||||||||||||||
| congenital merosin-deficient muscular dystrophy 1A | |||||||||||||||||||||||
| myopia |
| Mouse Phenotypes | abnormal cochlear hair cell morphology |
absent cochlear hair cells |
absent vestibular hair cells |
decreased brain weight |
abnormal Schwann cell morphology |
abnormal axon radial sorting |
abnormal cochlear nerve morphology |
decreased spinal cord weight |
abnormal myelination |
demyelination |
decreased nerve conduction velocity |
abnormal axonal transport |
enhanced long-term potentiation |
reduced long-term depression |
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| Availability | Mouse Genotype | ||||||||||||||
| Lama2dy-2J/Lama2dy-2J | |||||||||||||||
| Lama2dy-7J/Lama2dy-7J | |||||||||||||||
| Lama2dy/Lama2dy | |||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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